Sequel system
Single Molecule, Real-Time (SMRT) sequencing

Unlike most other sequencing technologies, the Sequel system doesn’t require clonal amplification of DNA – it sequences single molecules. Also, while it is a form of ‘sequencing by synthesis’, it operates in real-time rather than incorporating a single base (or type of base) at a time. The optical system is essentially taking a movie as the polymerase incorporates fluorescent nucleotides.